2007549
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Tricyclic Antidepressants, Quantitative, Serum or Plasma

TADQNT SP
Example Reports
High
Therapeutic

Ordering Recommendation

Use to optimize dosing and monitor patient adherence.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation

Timing of specimen collection: Predose (trough) draw at steady-state concentration.

Collect

Plain red. Also acceptable: Lavender (K2 or K3EDTA) or pink (K2EDTA).

Specimen Preparation

Separate serum or plasma from cells within 2 hours of collection. Transfer 1 mL serum or plasma to an ARUP standard transport tube. (Min: 0.5 mL)

Storage/Transport Temperature

Refrigerated.

Unacceptable Conditions

Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution).

Remarks
Stability

After separation from cells: Ambient: 5 days; Refrigerated: 2 weeks; Frozen: 6 months

Methodology

Quantitative Liquid Chromatography-Tandem Mass Spectrometry

Performed

Fri

Reported

2-8 days

Reference Interval

Drug
 Therapeutic Range
 Toxic
Amitriptyline (Elavil, Vanatrip) Not established Not established
Nortriptyline (Aventyl, Pamelor) 50-150 ng/mL Greater than 500 ng/mL
Total Amitriptyline + Nortriptyline 95-250 ng/mL Greater than 500 ng/mL
Imipramine (Tofranil) Not established Not established
Desipramine (Norpramin) 100-300 ng/mL Greater than 500 ng/mL
Total Imipramine + Desipramine 150-300 ng/mL Greater than 500 ng/mL
Doxepin (Sinequan, Zonalon) Not established Not established
Nordoxepin Not established Not established
Total Doxepin + Nordoxepin 100-300 ng/mL Greater than 500 ng/mL
Protriptyline (Vivactil) 70-240 ng/mL Greater than 400 ng/mL
Clomipramine (Anafranil) Not established Not established
Norclomipramine Not established Not established
Total Clomipramine + Norclomipramine 220-500 ng/mL Greater than 900 ng/mL

Interpretive Data

Urine concentrations of tricyclic antidepressants do not correlate with signs or symptoms of therapy or toxicity. Therapeutic ranges are not established.

Compliance Category

Laboratory Developed Test (LDT)

Note

This test is used to quantitate the following tricyclic antidepressants: amitriptyline, clomipramine, desipramine, doxepin, imipramine, norclomipramine, nordoxepin, nortriptyline, and protriptyline.

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
01/21/2025
X
02/20/2024
X
N/A

CPT Codes

80337 (Alt code: G0480)

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Components

Component Test Code* Component Chart Name LOINC
0090020 Amitriptyline/Nortriptyline, Total, SP 3335-7
0090024 Amitriptyline, SP 3333-2
0090065 Desipramine, SP 3531-1
0090100 Doxepin, SP 3579-0
0090101 Doxepin/Nordoxepin Total, SP 3582-4
0090105 Nordoxepin, SP 3862-0
0090106 Protriptyline, SP 3999-0
0090135 Imipramine/Desipramine Total, SP 9627-1
0090139 Imipramine, SP 3690-5
0090210 Nortriptyline, SP 3872-9
0099320 Clomipramine/Norclomipramine, Total, SP 3493-4
0099335 Norclomipramine, SP 3536-0
0099437 Clomipramine (Anafranil), SP 3491-8
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Tricyclic Antidepressant Screen
  • Tricyclic Screen
Tricyclic Antidepressants, Quantitative, Serum or Plasma